The UAB Department of Psychiatry is currently recruiting participants in the Birmingham area for a research study evaluating the safety, efficacy, and maintenance of effect of an investigational medication in people with major depressive disorder. Some participants may also be struggling with insomnia.

To qualify, you must:

be 18-74 years of age
be diagnosed with depression
have taken antidepressants in the past that did not work well for you
currently take an antidepressant medication but still have symptoms of MDD

The study will consist of two parts. In Part 1, participants will receive the investigational

medication or placebo for up to 6 weeks. Participants who complete Part 1 will have the option to participate in Part 2. In Part 2, participants will be subject to a second double blind phase with variable duration comparing the investigational medication to placebo for up to 16 weeks or more. Compensation will be provided for each completed session.

Qualified patients may receive study-required medical care and investigational study medication at no cost. The study will not pay for other medical care or current medication(s) needed to support personal daily health care routines.

For questions or comments, please contact:

Kristine Pike		Melissa Alexander
205-975-8542		205-996-5987
kristinepike@uabmc.edu		lalexander@uabmc.edu

Age

Have you ever been diagnosed with or treated for Major Depressive Disorder (MDD)?

Are you in a current Major Depressive Episode (i.e., feeling down or depressed most of the day nearly every day for at least the past 2 weeks?)

Have you ever been diagnosed with or treated for Bipolar Disorder?

Have you ever experienced psychotic features, such as hearing voices or seeing visions other people could not see or hear?

Are you currently being treated for Post-Traumatic Stress Disorder (PTSD)?

Are you currently taking an antidepressant for your depressive symptoms?

Which drug and what dosage?

How effective is your antidepressant at treating your depressive symptoms?

Do you currently have difficulty sleeping, such as trouble falling asleep or staying asleep?

Thank you for your interest in this study, unfortunately your answers indicate that you do not currently qualify at this time. If you are interested in learning about other research study opportunities at UAB please visit https://www.uab.edu/reporter/clinicaltrials.

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